V. Dall et al., INTERACTION OF THE COMPETITIVE AMPA RECEPTOR ANTAGONIST NBQX WITH HEXOBARBITAL, Pharmacology, biochemistry and behavior, 46(1), 1993, pp. 73-76
IP administration of hexobarbital to rats caused a mean sleeping time
of 93.6 min (SD 21.5). IV infusion of dihydroxy-6-nitro-7-sulfa-moyl-b
enzo(f)quinoxaline (NBQX) at a dose rate of 0.11 mg/kg/min starting 30
min after administration of hexobarbital prolonged the mean sleeping
time to 132.2 min (SD 14.9). Dose rates of 0.33 and 1.10 mg/kg/min pro
longed the mean sleeping times to 176.4 min (SD 33.3) and 444.1 min (S
D 72.0), respectively. Measured 180 and 450 min after the start of the
study, there were no differences in the plasma concentrations of hexo
barbital in groups receiving hexobarbital alone compared to groups rec
eiving the high-dose rate of NBQX starting 30 min after administration
of hexobarbital. The present results demonstrate that by IV infusion
NBQX dose dependently prolonged the sleeping time of hexobarbital. The
re were no indications of interactions on hexobarbital elimination of
either isomer. It is therefore likely that NBQX acts synergistically w
ith hexobarbital to depress the central nervous activity.