K. Suemaru et al., EFFECTS OF BETA-ADRENERGIC-RECEPTOR ANTAGONISTS ON NICOTINE-INDUCED TAIL-TREMOR IN RATS, Pharmacology, biochemistry and behavior, 46(1), 1993, pp. 131-133
The effects of various beta-adrenergic receptor antagonists on nicotin
e-induced tail-tremor were investigated in rats. Atenolol (5 and 10 mg
/kg, IP), arotinolol (5 and 10 mg/kg, IP), and carteolol (5 and 10 mg/
kg, IP), hydrophilic beta-adrenergic receptor antagonists, did not aff
ect the tail-tremor induced by nicotine given at a dose of 0.5 mg/kg S
C. However, propranolol (5-20 mg/kg, IP) and pindolol (5-20 mg/kg, IP)
, nonselective and lipophilic beta-adrenergic receptor antagonists, di
d suppress the tail-tremor dose dependently. In contrast, metoprolol (
5-20 mg/kg, IP), lipophilic and beta1-selective adrenergic receptor an
tagonists, did not show such an effect. These results suggest that nic
otine-induced tail-tremors may be mediated through central beta2-adren
ergic receptors as an appearance and developmental mechanism.