THERAPEUTIC EFFICACY OF A 30-300 KD PROTEIN-FRACTION VS GANGLIOSIDES IN THE TREATMENT OF DIABETIC NEUROPATHY - A PILOT-STUDY

The efficacy of treatment with a 30-300 KD protein fraction (4 mg/day for 30 days) on the symptoms of diabetic peripheral neuropathy and on electromyographic parameters has been studied in comparison to treatme nt with gangliosides (50 mg/day for 30 days) in two groups each of 8 p atients. Both treatments resulted in comparable improvement of neurolo gical symptoms on clinical evaluation. However, electromyographic para meters in patients treated with the 30-300 KD protein fraction showed greater changes than those of patients who were given gangliosides. Th ese results may encourage the clinical use of this protein fraction in the treatment of diabetic peripheral neuropathy, but need to be confi rmed in a large controlled study.