A quantum problem on an isospectral deformation of one-dimensional pot
entials (and of corresponding wave functions) is considered. The isosp
ectral deformation defined in the form of a phase flow is shown to obe
y a system of coupled Liouville equations. In a simple case of an indi
vidual flow the well-known integrable Liouville equation arises; its s
olution provides known families of isospectral potentials. Operators p
erforming this deformation are studied; their unitary property is prov
ed. An evolution of spectral shift operators is determined using those
unitary operators. An asymptotical behavior of both a potential and w
ave functions under this isospectral deformation is studied. It is sho
wn, in particular, that the deformation of the Rosen-Morse potential a
nd that of the harmonic oscillator's potential have common analytical
properties. The approach used in the paper can be extended to the case
of a deformation leading to a shift of one selected energy level. In
the case of the simplest individual flow we get a generalization of th
e integrable Liouville equation.