Neuroleptic-induced akathisia (NIA) is the most common form of extrapy
ramidal symptoms (EPS). It is often refractory to treatment and its pr
esence may preclude adequate trials of antipsychotics. Two patients, w
ith other indications for bupropion (BUP) therapy, demonstrated modera
te to severe NIA which responded dramatically to BUP. This improvement
was sustained. These serendipitous observations require replication,
but further study appears warranted. As BUP lowers the seizure thresho
ld, additional studies must be undertaken with great caution.