GENETIC-MARKERS IN PRIMARY OPEN-ANGLE GLAUCOMA

Purpose: To investigate possible associations between genetic markers and Primary Open-Angle Glaucoma (POAG). Methods: A number of genetic m arkers were typed in 84 unrelated patients with POAG and compared with a random sample of healthy individuals. The markers were Transferrin, Group Specific Component, G1m (1), Glm (2) and G3m (5) Allotypes, Ade nylate Kinase, Adenosin Deaminase, Glyoxalase I and Acid Phosphatase a nd PCR-based markers HLA-DQA1 and D1S80. Results: No significant diffe rences were found except the strong association between the group of P OAG patients and Acid Phosphatase ACP()C allele (chi(2) = 32.86; p < 0.0001). Conclusions: Since Acid Phosphatase gene is localized lo chro mosome 2p23, this result could be a first comprehensive step in the lo calization of POAG genes.