KANAMYCIN CONCENTRATIONS IN SYNOVIAL-FLUID AFTER INTRAMUSCULAR ADMINISTRATION IN THE HORSE

Six adult ponies were injected in the same intramuscular site with kan amycin sulphate (10 mg/kg). Two hours later, arthrocenteses of the rig ht metacarpophalangeal, radio-carpal, intercarpal, tibio-tarsal and me tatarsophalangeal joints were performed within 3 minutes. Arthrocentes es of the same joints on the left side were conducted 5 hours later. W hen expressed as a percentage of plasma drug concentration, difference s in synovial fluid drug concentration between the joints sampled at 2 and 5 hours after injection were not detected.