B. Lejczak et al., INHIBITION OF AMINOPEPTIDASES BY PHOSPHONIC ACID AND PHOSPHINIC ACID ANALOGS OF ASPARTIC AND GLUTAMIC ACIDS, Journal of enzyme inhibition, 7(2), 1993, pp. 97-103
More than 30 phosphonic and phosphinic acid analogues of aspartic and
glutamic acids were synthesized in order to probe how the structural d
ifferences of these molecules were reflected in their ability to inhib
it cytosolic (LAP) and microsomal (APM) aminopeptidases. Although most
of the compounds studied were found to exert only a modest inhibitory
effect, the studies provide some information on the structural requir
ements of the binding subsites and catalytic centers of both enzymes.