EFFECT OF LONG-TERM ORAL TESTOSTERONE UNDECANOATE TREATMENT ON PROSTATE VOLUME AND SERUM PROSTATE-SPECIFIC ANTIGEN CONCENTRATION IN EUGONADAL MIDDLE-AGED MEN

Authors
HOLMANG S MARIN P LINDSTEDT G HEDELIN H
Citation
S. Holmang et al., EFFECT OF LONG-TERM ORAL TESTOSTERONE UNDECANOATE TREATMENT ON PROSTATE VOLUME AND SERUM PROSTATE-SPECIFIC ANTIGEN CONCENTRATION IN EUGONADAL MIDDLE-AGED MEN, The Prostate, 23(2), 1993, pp. 99-106
Citations number
25
Categorie Soggetti
Endocrynology & Metabolism
Journal title
The Prostate → ACNP
ISSN journal
02704137
Volume
23
Issue
2
Year of publication
1993
Pages
99 - 106
Database
ISI
SICI code
0270-4137(1993)23:2<99:EOLOTU>2.0.ZU;2-N
Abstract
Testosterone undecanoate (160 mg/day) or placebo was given orally in a double-blind fashion for 8 months to 23 middle-aged men without urina ry tract symptoms. Testosterone was found to increase the mean prostat e volume by 12% (P < .012). The treatment suppressed the serum concent rations of sex-hormone-binding globulin and follicle stimulating hormo ne. The observed decrease in the mean serum concentration of luteinizi ng hormone was not statistically significant. The serum concentrations of prostate-specific antigen did not change as measured by two differ ent well-validated immunometric assays. No changes in micturition habi ts or urine flow charts were reported. (C) 1993 Wiley Liss, Inc.