SPINDLE-CELL HEMANGIOENDOTHELIOMA - A REPORT OF 2 CASES

Two cases of spindle cell hemangioendothelioma (SCH) are reported. One of the patients was a 16 year old Japanese female, who had been suffe ring from Ollier's disease (multiple enchondromatosis) since 3 years o f age and had developed multiple SCH in the right leg at the age of 11 years. Spindle cell hemangioendothelioma lesions coincided with the s ite of enchondromatosis and increased in number thereafter. This is th e first report of Ollier's disease complicated with multiple SCH. Anot her patient, a 33 year old Japanese female, who was a carrier of hepat itis B virus (HBV), developed solitary SCH in the lateral aspect of th e right ankle where a lipoma was extirpated 10 years previously. Tumor cells of both cases were composed of four cell types: (i) spindle cel ls; (ii) epithelioid cells; (iii) vacuolated endothelial cells; and (i v) usual endothelial cells. Endothelia in the cavernous area and vacuo lated cells reacted to Ulex europaeus agglutin 1 (UEA-1), factor VIII- related antigen and vimentin. Spindle cells and epithelioid cells reac ted only to vimentin.