BRAIN PERFUSION SPECT IN CHILDREN WITH FREQUENT FITS

We studied 14 children with frequent fits using Tc-99m-HM-PAO single p hoton emission computed tomography (SPECT). There were 11 patients wit h partial secondary generalized epilepsy (psGE) and 3 with Lennox-Gast aut syndrome (LGS). The typical regional cerebral blood flow (rCBF) fi nding in PSGE was a single area of abnormally low perfused cortex, and that in LGS, multiple hypoperfused areas. Clinically, the LGS patient s were more severely affected. SPECT was more sensitive in detecting a bnormalities than EEG, CT or MRI. Extensive impairment of rCBF may thu s indicate unfavourable development of intellectual performance and po or seizure control.