CANDIDA-TROPICALIS ARTHRITIS IN A PATIENT WITH ACUTE MYELOID-LEUKEMIASUCCESSFULLY TREATED WITH FLUCONAZOLE - CASE-REPORT AND REVIEW OF THELITERATURE

The case of a 77-year-old woman with acute myeloid leukemia who develo ped Candida tropicalis septic arthritis of the knee after remission-in ducing chemotherapy is reported. A literature review of C, tropicalis non-prosthetic arthritis is included. The isolate was susceptible to f luconazole (MIG 0.25 mg/l). She was treated with fluconazole (400 mg o rally) and frequent relieving synovial aspirations. After 1 month of a ntifungal therapy the synovial fluid became culture negative. Fluconaz ole concentration in the synovial fluid and serum were 20 mg/l and 19. 4 mg/l, respectively. The patient was treated for a total of 7 months and made a full recovery. This is the first report of the successful u se of fluconazole in the treatment of septic arthritis due to C, tropi calis.