THE SYNTHESIS OF MODIFIED ACHIRAL INTERNUCLEOSIDE LINKAGES - NHCH2CH2-LINKED OLIGONUCLEOSIDES

Authors
SAHA AK SCHAIRER W WAYCHUNAS C PRASAD CVC SARDARO M UPSON DA KRUSE LI
Citation
Ak. Saha et al., THE SYNTHESIS OF MODIFIED ACHIRAL INTERNUCLEOSIDE LINKAGES - NHCH2CH2-LINKED OLIGONUCLEOSIDES, Tetrahedron letters, 34(38), 1993, pp. 6017-6020
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
38
Year of publication
1993
Pages
6017 - 6020
Database
ISI
SICI code
0040-4039(1993)34:38<6017:TSOMAI>2.0.ZU;2-I
Abstract
A method for the synthesis of oligonucleosides uniformly linked by the NHCH2CH2 moiety is described. Syntheses of heterodimers and a thymidy late trimer along with relevant T(m) and nuclease resistance data are described.