MUTANT AND TRANSGENIC MICE IN IMMUNOTOXICOLOGY - AN INTRODUCTION

An overview is given in simple terms of the techniques behind transgen ic, knock-out and knock-in mice. The principles for the creation and u se in toxicology of genetically engineered animals are outlined, and s ome examples are given from areas related to immunotoxicology. Genetic ally engineered animals have so far been used only to a very limited e xtent in immunotoxicology. Practical aspects of work with transgenic a nimals are discussed, and sources of information and services related to transgenic animals are listed. (C) 1997 Elsevier Science Ireland Lt d.