NEDOCROMIL SODIUM VS SODIUM CROMOGLYCATE PRESSURIZED AEROSOL IN THE PREVENTION OF BRONCHOCONSTRICTION INDUCED BY ULTRASONIC NEBULIZED DISTILLED WATER IN ASTHMATIC-CHILDREN

To compare the effectiveness of nedocromil sodium (NS) and sodium crom oglycate (SCG), administered by metered dose inhaler (MDI) with a 700 mL holding chamber (Fisonair Fisons UK) in preventing bronchoconstrict ion induced by inhalation of ultrasonically nebulized distilled water (UNDW), 12 asthmatic children were studied in a randomized, double-bli nd, placebo-controlled, intrapatient study. Following a baseline chall enge with UNDW, the protective effect of NS, SCG, or placebo was evalu ated in each subject. Cumulative doses of delivered nebulized water pr oducing a 20% fall in forced expiratory volume in 1 sec (PD20 UNDW) wa s measured. Mean (+/- SD) PD20 UNDW was 4.83 (+/- 4.84), 10.16 (+/- 7. 05),15.8 (+/- 0.5), and 15.93 (+/- 0.23) respectively, for baseline, a nd placebo, SCG, and NS-treated groups. A significant (P < 0.05) prote ction from UNDW induced bronchoconstriction by NS was observed in comp arison with placebo, while no such effect was evident when the childre n were treated with SCG. (C) 1993 Wiley-Liss, Inc.