Sixty-five patients with symptomatic pancreas divisum were treated by
endostents, surgery, or observation. In 35 patients, endoscopic stenti
ng either alone (20) or followed by surgery (15) was the primary thera
py. Of 30 patients not stented, 10 underwent elective surgery and 20 w
ere followed. Treatment was based on symptoms and biochemical and radi
ologic tests. The results of surgical decompression correlated favorab
ly with endoscopic drainage. In untreated patients, the natural histor
y of pancreas divisum was benign. Surgery is safe and effective in sym
ptomatic patients, although multiple operations may be required for re
current symptoms or progressive disease.