EFFECT OF MANGO GINGER [CURCUMA-AMADA ROXB] ON TRITON WR-1339 INDUCED-HYPERLIPIDEMIA AND PLASMA LIPASES ACTIVITY IN THE RAT

When 10 percent dry mango ginger was fed in normal diets to adult fema le wistar rats for 4, weeks, the liver, serum total and [VLDL+LDL] tri glycerides were lowered. In animals which were rendered hypertriglycer idemic by feeding a sucrose-rich diet and subsequently fed the mango g inger diet, the liver or serum triglyceride only tended to be lower. I n mango ginger fed animals, the increase in liver and blood lipids aft er Triton WR-1339 treatment were significantly lower than in control d iet fed animals. This effect of mango ginger was also observed in anim als fed the equivalent of 0.3% curcumin-free extract but not in those fed the 10% curcumin containing portion of mango ginger. In both these groups, the lipoprotein lipase activities were elevated as with mango ginger fed group. The hypotriglyceridemic activity of mango ginger ap pears to be mediated through influences on both liver synthesis and bl ood clearance.