PROTEIN B23 IS AN IMPORTANT HUMAN FACTOR FOR THE NUCLEOLAR LOCALIZATION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS PROTEIN TAT

Authors
LI YP
Citation
Yp. Li, PROTEIN B23 IS AN IMPORTANT HUMAN FACTOR FOR THE NUCLEOLAR LOCALIZATION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS PROTEIN TAT, Journal of virology, 71(5), 1997, pp. 4098-4102
Citations number
22
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
71
Issue
5
Year of publication
1997
Pages
4098 - 4102
Database
ISI
SICI code
0022-538X(1997)71:5<4098:PBIAIH>2.0.ZU;2-B
Abstract
Nucleolar shuttle protein B23 was found to bind to human immunodeficie ncy virus protein Tat, and this binding required the nucleolar localiz ation motif of Tat. A fusion protein containing the B23 binding domain and beta-galactosidase caused mislocalization of Tat to the cytoplasm and inhibited the transactivation activity of Tat, These data suggest that B23 is a human factor necessary for the nucleolar localization o f Tat.