COLUMBIA ATYPICAL DEPRESSION - A SUBGROUP OF DEPRESSIVES WITH BETTER RESPONSE TO MAOI THAN TO TRICYCLIC ANTIDEPRESSANTS OR PLACEBO

We summarise a series of studies using a MAOI to help establish the va lidity of a subgroup of depressives referred to as atypical depressive s. Patients with reactive mood meeting DSM-III criteria for depressive illness who had associated atypical features (which include hyperphag ia, hypersomnolence, leaden paralysis, and rejection sensitivity) were randomised to imipramine, phenelzine and placebo. Non-responders were crossed over, and in all there were over 400 patient trials. Phenelzi ne consistently was found to be superior to imipramine. Only in trials which included patients lacking atypical, vegetative symptoms was imi pramine found to equal phenelzine. We conclude that the researcher and the clinician should consider the relevance of the atypical depressiv e syndrome.