COMPARISON OF LIQUID-CHROMATOGRAPHIC METHODS FOR ANALYSIS OF HOMOLOGOUS ALKYL ESTERS OF BIPHENYL-4,4'-DICARBOXYLIC ACID

Homologous series of compounds are generated in systematic studies of liquid crystals, petroleum fractions and pharmaceutical compounds. The paper describes the separation of a series of homologous liquid cryst alline alkyl esters of biphenyl-4,4,'-dicarboxylic acid.by high-perfor mance liquid chromatography. High-performance gel-permeation chromatog raphy (HPGPC) was capable of separating compounds differing by a singl e carbon, and is, therefore, similar in resolving power to either norm al- or reversed-phase liquid chromatography. High-performance gel-perm eation chromatography has the advantage of permitting the analysis of compounds of widely differing polarity. If the resolution of GPC can b e increased slightly by reducing the particle size and decreasing the pore size to maximize resolution in the range of 250-500 u, it could b ecome a primary analytical technique in the organic synthetic laborato ry.