M. Lambert et al., LYMPHOKINE GENE-TRANSCRIPTION IN CD4- T-CELLS OF A TYPE-III BARE LYMPHOCYTE SYNDROME PATIENT(CD8), Human immunology, 37(3), 1993, pp. 143-148
In this study we analyzed the impact of a MHC class-II-deficient envir
onment on the differentiation of CD4+ CD8- T lymphocytes into function
al defined subsets of lymphokine-producing T-helper cells. To this end
a CD4+ CD8- T-cell line and CD4+ CD8- T-cell clones, isolated from PB
MCs of a type III BLS patient, were stimulated in vitro with anti-CD3
and PMA and assessed for lymphokine transcription patterns. The result
s of these analyses show that CD4+ CD8- T cells that have matured in a
MHC class-II-deficient environment display lymphokine transcription p
atterns that resemble those of MHC class-II-expressing family control-
derived CD4+ CD8- T cells.