STRUCTURE OF MALOLACTOMYCIN-A AND MALOLACTOMYCIN-B, NOVEL 40-MEMBEREDMACROLIDE ANTIBIOTICS

Authors
KOSHINO H KOBINATA K UZAWA J URAMOTO M ISONO K OSADA H
Citation
H. Koshino et al., STRUCTURE OF MALOLACTOMYCIN-A AND MALOLACTOMYCIN-B, NOVEL 40-MEMBEREDMACROLIDE ANTIBIOTICS, Tetrahedron, 49(39), 1993, pp. 8827-8836
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
49
Issue
39
Year of publication
1993
Pages
8827 - 8836
Database
ISI
SICI code
0040-4020(1993)49:39<8827:SOMAMN>2.0.ZU;2-Q
Abstract
Malolactomycins A and B are novel 40-membered polyol macrolide antifun gal antibiotics which have hemiacetal, malonate and dimethylguanidyl g roups. Malolactomycins A and B are positional isomers of malonate and interconvertible each other by transesterification. The structures of malolactomycins A and B have been determined by spectroscopic analyses , especially NMR for the parent antibiotics and MS for the oxidative p roduct.