Research in experimental psychosis has a long tradition extending thro
ugh several stages. With the world wide abuse of psychoactive substanc
es it came to an abrupt end. Systematic questions within this framewor
k of research are still unresolved, and research on newly developed co
mpounds is almost completely lacking. A review of the pharmacological
and psychological effects of various psychoactive agents is provided,
and results of recent experimental studies on arylalkanamines are disc
ussed. It is argued that from a systematic as well as from a methodolo
gical viewpoint the traditional approach of experimental psychosis rep
resents a valuable tool in psychiatric research.