COMBINED USE OF HYDROXYAPATITE AND TISSEEL(R) IN EXPERIMENTAL BONE DEFECTS IN THE RABBIT

An experimental study in the rabbit has been undertaken to evaluate di fferences in bone regeneration in and around solid (Alveograf(R)) and porous (Interpore 200(R)) hydroxyapatite granulae. Material was placed into experimentally made bone defects and in half of the defects HA w as also mixed with fibrin sealent (Tisseel(R)). Material alone or mixe d with Tisseel(R) was also placed subperiosteally adjacent to the mand ibular bone. The observation time was six months. The study showed, ho wever, no difference in bone regeneration around solid or porous hydro xyapatite granula nor could we see differences when mixed with Tisseel (R) or not. Implant material placed subperiosteally did not induce bon e formation nor did it provoke bone resorption. The use of fibrin seal ant (Tisseel(R)) made the hydroxyapatite material much more easy to ha ndle and to retain in the tissue.