CULTURE MODEL FOR THE STUDY OF CEREBRAL MALARIA - ANTIBODIES FROM PLASMODIUM-FALCIPARUM-INFECTED COMATOSE PATIENTS INHIBIT THE DENDRITIC DEVELOPMENT OF PURKINJE-CELLS
Mc. Calvet et al., CULTURE MODEL FOR THE STUDY OF CEREBRAL MALARIA - ANTIBODIES FROM PLASMODIUM-FALCIPARUM-INFECTED COMATOSE PATIENTS INHIBIT THE DENDRITIC DEVELOPMENT OF PURKINJE-CELLS, Journal of neuroscience research, 36(2), 1993, pp. 235-240
The in vitro development of kitten Purkinje cells was inhibited by ser
a or IgG from cerebral malaria (CM) patients but not by sera from acut
e non-complicated malaria (NCM) cases. This inhibitory effect, quantif
ied by computer-assisted methods, concerned the dendritic (though not
the axonal) development and was found to be related to the presence in
CM sera of self-reactive antibodies of the IgG class. These results s
uggest that protection acquired against the major complication of Plas
modium falciparum malaria may correspond to the repression of an abnor
mal stimulation of autoreactive B cells. (C) 1993 Wiley-Liss, Inc.