PITUITARY ADENYLATE-CYCLASE ACTIVATING PEPTIDE AND VASOACTIVE INTESTINAL POLYPEPTIDE - DIFFERENTIATION EFFECTS ON HUMAN NEUROBLASTOMA NB-OK-1 CELLS

Authors
HOSHINO M LI M ZHENG LQ SUZUKI M MOCHIZUKI T YANAIHARA N
Citation
M. Hoshino et al., PITUITARY ADENYLATE-CYCLASE ACTIVATING PEPTIDE AND VASOACTIVE INTESTINAL POLYPEPTIDE - DIFFERENTIATION EFFECTS ON HUMAN NEUROBLASTOMA NB-OK-1 CELLS, Neuroscience letters, 159(1-2), 1993, pp. 35-38
Citations number
16
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
159
Issue
1-2
Year of publication
1993
Pages
35 - 38
Database
ISI
SICI code
0304-3940(1993)159:1-2<35:PAAPAV>2.0.ZU;2-Y
Abstract
Pituitary adenylate cyclase activating peptide-38 (PACAP-38), PACAP-27 and vasoactive intestinal polypeptide (VIP) increased intracellular c AMP content in human neuroblastoma NB-OK-1 cells transiently. PACAP an d VIP also arrested cell growth and induced morphological differentiat ion, which lasted for 24 h in spite of removal of PACAP-38 and PACAP-2 7. The order of potencies for the neurite outgrowth and the arrest of cell growth is PACAP-38 > PACAP-27 > VIP. The results suggest the poss ibility that these neuropeptides are new candidates for differentiatio n activity.