SYNTHESIS OF BOTH D-FMOC-ABU[PO(OCH2CH=CH2)2]-OH AND L-FMOC-ABU[PO(OCH2CH=CH2)2]-OH FOR SOLID-PHASE PHOSPHONOPEPTIDE SYNTHESIS

Authors
SHAPIRO G BUECHLER D OJEA V POMBOVILLAR E RUIZ M WEBER HP
Citation
G. Shapiro et al., SYNTHESIS OF BOTH D-FMOC-ABU[PO(OCH2CH=CH2)2]-OH AND L-FMOC-ABU[PO(OCH2CH=CH2)2]-OH FOR SOLID-PHASE PHOSPHONOPEPTIDE SYNTHESIS, Tetrahedron letters, 34(39), 1993, pp. 6255-6258
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
39
Year of publication
1993
Pages
6255 - 6258
Database
ISI
SICI code
0040-4039(1993)34:39<6255:SOBDAL>2.0.ZU;2-A
Abstract
The Schollkopf bislactim ether asymmetric amino acid synthesis was cou pled with a subsequent enzyme mediated ester hydrolysis to generate a practical synthesis of both D and L enantiomers of Fmoc-Abu[PO(OCH2CH= CH2)2]-OH (6). With this building block phosphonopeptide isosteres of serine phosphopeptides are accessible by Fmoc-solid phase peptide synt hesis.