ARAGUSTEROL-A - A POTENT ANTITUMOR MARINE STEROID FROM THE OKINAWAN SPONGE OF THE GENUS, XESTOSPONGIA

Authors
IGUCHI K FUJITA M NAGAOKA H MITOME H YAMADA Y
Citation
K. Iguchi et al., ARAGUSTEROL-A - A POTENT ANTITUMOR MARINE STEROID FROM THE OKINAWAN SPONGE OF THE GENUS, XESTOSPONGIA, Tetrahedron letters, 34(39), 1993, pp. 6277-6280
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
39
Year of publication
1993
Pages
6277 - 6280
Database
ISI
SICI code
0040-4039(1993)34:39<6277:A-APAM>2.0.ZU;2-K
Abstract
Aragusterol A, a new marine steroid possessing potent antitumor activi ty, was isolated from the Okinawan sponge of the genus Xestospongia an d its structure was determined by spectroscopic analysis and chemical evidence. The compound strongly inhibited the cell proliferation of KB , HeLaS3, P388 and LoVo cells in vitro, and also showed potent in vivo antitumor activity toward P388 in mice and L1210 in mice.