PHYSALIN AND NEOPHYSALINS FROM PHYSALIS-ALKEKENGI VAR FRANCHETI AND THEIR DIFFERENTIATION-INDUCING ACTIVITY

Authors
SUNAYAMA R KUROYANAGI M UMEHARA K UENO A
Citation
R. Sunayama et al., PHYSALIN AND NEOPHYSALINS FROM PHYSALIS-ALKEKENGI VAR FRANCHETI AND THEIR DIFFERENTIATION-INDUCING ACTIVITY, Phytochemistry, 34(2), 1993, pp. 529-533
Citations number
15
Categorie Soggetti
Plant Sciences
Journal title
Phytochemistry → ACNP
ISSN journal
00319422
Volume
34
Issue
2
Year of publication
1993
Pages
529 - 533
Database
ISI
SICI code
0031-9422(1993)34:2<529:PANFPV>2.0.ZU;2-V
Abstract
A methanol extract of Physalis alkekengi var.francheti showed a potent cell differentiation inducing activity toward mouse myeloid leukemia cell line (M1 cells). From the extract, a new physalin and two new neo physalins, 25,27-dihydro-4,7-didehydro-7-deoxyneophysalin A and 4,7-di dehydroneophysalin B, were isolated along with physalin A, L and isoph ysalin B. The structures of physalins and neophysalins were determined by means of NMR, UV, IR and mass spectra. Of these compounds, physali n A showed potent cell differentiation inducing activity.