MULTIPLE NODULES OF INTERMEDIATE TROPHOBLAST FOLLOWING HYDATIDIFORM MOLES

After removal of a complete hydatidiform mole, seven patients develope d an unusual complication characterized by a proliferation of intermed iate trophoblast-forming nodules in the endometrium or myometrium. The patients were examined because of vaginal bleeding or mildly elevated human chorionic gonadotrophin (HCG) titers. Three patients were cured by hysterectomy, one by endometrial curettage, one by endometrial cur ettage plus chemotherapy, and one (who also had choriocarcinoma) by mu ltiple doses of chemotherapy after hysterectomy; the seventh patient w as lost to follow-up. These nodules probably represent a mild form of postmolar trophoblastic disease.