This review deals with some of the most controversial problems in the
field of immunologic infertility and antisperm antibodies (ASA) in hum
ans: (a) sperm antigens and their identification; (b) the aetiopathoge
nesis of the immune reaction and the biological effects of ASA; (c) la
boratory tests set up for ASA detection, and (d) the therapy for immun
ologic infertility both in vivo and in vitro.