PAF ACTIVATION OF A VOLTAGE-GATED R-TYPE CA(2-CELLS() CHANNEL IN HUMAN AND CANINE AORTIC ENDOTHELIAL)

Authors
BKAILY G DORLEANSJUSTE P NAIK R PERODIN J STANKOVA J ABDULNOUR E ROLAPLESZCZYNSKI M
Citation
G. Bkaily et al., PAF ACTIVATION OF A VOLTAGE-GATED R-TYPE CA(2-CELLS() CHANNEL IN HUMAN AND CANINE AORTIC ENDOTHELIAL), British Journal of Pharmacology, 110(2), 1993, pp. 519-520
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
British Journal of Pharmacology → ACNP
ISSN journal
00071188
Volume
110
Issue
2
Year of publication
1993
Pages
519 - 520
Database
ISI
SICI code
0007-1188(1993)110:2<519:PAOAVR>2.0.ZU;2-Y
Abstract
By the use of fura-2 and digital imaging techniques, [K]o depolarizati on or PAF (10(-9)M) were shown to induce a sustained increase of [Ca]i in human or canine single aortic vascular endothelial cells (VEC) tha t was insensitive to nifedipine but sensitive to (-)-PN200-110 or to l owering of [Ca]o. The PAF-induced effect on [Ca]i was blocked by the P AF receptor antagonist, WEB2170. Our results suggest that [K]o depolar ization and PAF increase [Ca]i via the activation of R-type Ca2+ chann els.