VIBRATIONAL DYNAMICS OF WET-SPUN FILMS OF THE NADNA-NETROPSIN COMPLEX- A RAMAN AND INFRARED STUDY

Raman spectroscopy and infrared absorption have been used to study the vibrational dynamics of wet-spun films of the NaDNA-netropsin (NaDNA- net) complex as well as netropsin and NaDNA. The NaDNA-net complex is found to have a substantially different vibrational spectrum from eith er netropsin or NaDNA. The films of NaDNA-net appear to be more crysta lline than the films of NaDNA alone. The formation of the NaDNA-net co mplex strongly favors the B conformation of the double helix. These vi brational data provide useful information for the understanding of the nature of the interaction of DNA with the antiviral, antitumor antibi otic netropsin.