WALDENSTROM HYPERGAMMAGLOBULINEMIC PURPURA AND PREGNANCY

Background: Waldenstrom hypergammaglobulinemic purpura is characterize d by hypergammaglobulinemia, recurring purpura, and an elevated erythr ocyte sedimentation rate. It is a rare disease and, to our knowledge, there have been no previous reports of its presence during pregnancy. We report a patient with this disease whose pregnancy was complicated by severe fetal growth restriction (FGR) and acute fetal distress. Cas e: A 24-year-old primigravid woman with a history of Waldenstrom hyper gammaglobulinemic purpura and renal insufficiency developed FGR at 32 weeks' gestation. Cesarean delivery was performed at 33.5 weeks becaus e of acute fetal distress, and a 1305-g male infant was delivered. Neo natal outcome was successful. No deterioration of the woman's medical condition occurred during or after her pregnancy. Conclusion: Successf ul pregnancy outcome is possible in women with Waldenstrom hypergammag lobulinemic purpura. In view of the risk of FGR, close monitoring of f etal growth and well-being is recommended in women with this condition .