Hb. Gehl et al., MANGANESE DIPYRIDOXAL DIPHOSPHATE (MNDPDP ) - A NEW CONTRAST-MEDIUM FOR MRT OF BENIGN AND MALIGNANT PANCREATIC TUMORS - EARLY CLINICAL-EXPERIENCE, RoFo. Fortschritte auf dem Gebiete der Rontgenstrahlen und der neuenbildgebenden Verfahren, 159(3), 1993, pp. 240-244
MnDPDP ist a new intracellular contrast medium of which 50 % is excret
ed through the bile; its acceptability and effect on MR images was stu
died in 21 patients, 18 of whom had malignant and three benign tumours
of the pancreas. Spin echo T1 images (SE-T1: TR = 500 ms; TE = 15 ms)
showed a 20 % increase in signal to noise ratio (S / N) (p = 0.059) a
nd a 90 % increase in contrast to noise ratio (C/N) (p = 0.0027). In g
radient T1 images (GE-T1: TR = 100 ms; TE = 6 ms; flip angle = 70-degr
ees) there was an increase of S/N of 70% (p < 0.0001) and of the C/N o
f 200% (p < 0.0001). T2 weighted SE sequences were inferior to plain S
E-T1 weighted sequences with regard to their S/N and C/N ratios. There
were no significant clinical complications or biochemical changes in
the blood or urine. A subjective side effect in three patients was a f
eeling of heat. MnDPDP is a well tolerated and effective contrast medi
um for MRT of pancreatic tumours.