HOW MUCH HYDRATION IS NECESSARY FOR THE STABILIZATION OF DNA-DUPLEX

Authors
MALTSEVA TV AGBACK P CHATTOPADHYAYA J
Citation
Tv. Maltseva et al., HOW MUCH HYDRATION IS NECESSARY FOR THE STABILIZATION OF DNA-DUPLEX, Nucleic acids research, 21(18), 1993, pp. 4246-4252
Citations number
30
Categorie Soggetti
Biology
Journal title
Nucleic acids research → ACNP
ISSN journal
03051048
Volume
21
Issue
18
Year of publication
1993
Pages
4246 - 4252
Database
ISI
SICI code
0305-1048(1993)21:18<4246:HMHINF>2.0.ZU;2-H
Abstract
A combination of NOESY and ROESY experiments show that the higher stab ilities (T(m)) of phenazine tethered matched (2) and G-A mismatched (4 ) DNA duplexes are due to the decrease of the exchange-rate (i.e. incr ease of the life-time) of the imino-protons and the reduced water acti vity in their minor grooves compared to their non-tethered counterpart s (1) and (3).