Authors
Citation
Bd. Maxwell, THE RADIOLABELED SYNTHESIS OF -2-CHLORO-6-TRIMETHYLSILYLBENZAMIDE[RING-C-14(U)], A FUNGICIDE CANDIDATE FOR WHEAT TAKE-ALL DISEASE, Journal of labelled compounds & radiopharmaceuticals, 39(4), 1997, pp. 267-273
Citations number
5
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
ISSN journal
03624803
Volume
39
Issue
4
Year of publication
1997
Pages
267 - 273
Database
ISI
SICI code
0362-4803(1997)39:4<267:TRSO->2.0.ZU;2-V
Abstract
N-Ethyl-2-chloro-6-trimethylsilylbenzamide [Ring-14C(U)], 6(1), was sy
nthesized in five steps from [U-C-14]-benzoic acid 1 in an overall yie
ld of 71%. Two key steps in the synthesis involve directed ortho metal
ation reactions(2) on the aromatic ring. Purification by Silica gel Fl
ash Column Chromatography produced 6 with a radiochemical purity of 99
%.