SYNTHESIS OF [(17)-C-14] NICERGOLINE

Authors
ANGIULI P FONTANA E DOSTERT P
Citation
P. Angiuli et al., SYNTHESIS OF [(17)-C-14] NICERGOLINE, Journal of labelled compounds & radiopharmaceuticals, 39(4), 1997, pp. 331-337
Citations number
12
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
39
Issue
4
Year of publication
1997
Pages
331 - 337
Database
ISI
SICI code
0362-4803(1997)39:4<331:SO[N>2.0.ZU;2-I
Abstract
The synthesis of 1,6-dimethyl-8 beta-(5-bromonicotinoyl-[C-14]10 alpha -methoxy-ergoline ([17-C-14] nicergoline) is reported. A five-step rou te starting from the addition of potassium [C-14] cyanide 2 to 1,6-dim ethyl-8 beta-chloro-10 alpha-methoxy-ergoline 1 yielded the expected [ 17-C-14] nicergoline, 97% radiochemically pure, with a specific activi ty of 2.23 GBq/mmol. The overall radiochemical yield was about 10% fro m 2.