We derive a general Boltzmann-type collision integral for mixed neutri
nos interacting with each other and with a medium. Our treatment is fu
lly relativistic in that antineutrino degrees of freedom are included.
This collision integral allows one to account for the simultaneous ef
fects of neutrino oscillations in a medium and for the effects of coll
isions. Our result generalizes previous attempts of unify the first- a
nd second-order interaction effects in a single self-consistent equati
on. Most importantly, our equation includes effects non-linear in the
neutrino density matrices (or occupation numbers) such as Pauli blocki
ng of neutrino final states or neutrino refraction in a medium of neut
rinos. We apply the definition of the entropy of a non-equilibrium Fer
mi gas to the case of mixed neutrinos, and we prove that our collision
integrals obey the relevant thermodynamic inequalities.