An ethanol extract of the leaves of Piper aduncum demonstrated good an
timicrobial activity. Bioassay-directed fractionation of this extract
led to the isolation of 4-methoxy-3,5-bis(3'-methylbenzoic acid) 1,2,6
-dihydroxy-4-methoxy-chalcone 2, nervogenic acid 3 and xy-8-(3-methyl-
2-butenyl)-2H-chromene-6-carboxylic acid 4. These compounds showed con
siderable in vitro antifungal and antibacterial activity. (C) 1997 by
John Wiley & Sons, Ltd.