GASTRIC-MUCOSAL BLOOD-FLOW AND NEUTROPHIL ACTIVATION IN ASPIRIN-INDUCED GASTRIC-MUCOSAL DAMAGE IN MAN

Gastric and intestinal injury induced by nonsteroidal anti-inflammator y agents (NSAIDs) such as aspirin (ASA) is a common side effect of thi s class of drugs, but the mechanism by which these drugs act is not fu lly explained. In this study the effects of 3 days of continuous oral ASA administration (1 g twice daily) to eight healthy male volunteers were studied. To estimate the extent of mucosal damage, gastroscopy wa s performed before and after 3 days of ASA treatment, during which the mucosal blood flow was measured by means of laser-Doppler flowmetry. Before each endoscopy gastric microbleeding was measured. Since neutro phil activation has recently been suggested to be involved in the path ogenesis of ASA-induced gastric mucosal damage, we examined the influe nce of ASA treatment on the activation of leukocytes by determining th eir association with platelets in the blood. Aspirin-induced acute gas tric damage reached about 3.5 in the endoscopic Lanza score. Mucosal b lood flow increased significantly after ASA treatment, by about 50% in the oxyntic gland area and by 87% in the antral area. Gastric microbl eeding rose from about 0.38 ml/day in the intact stomach to about 7.7 ml/day after ASA treatment. The platelet/neutrophil adherence increase d significantly in both thrombin-unstimulated and thrombin-stimulated platelets. We conclude that acute 3 days' administration of ASA in man produces well-defined areas of gastric damage accompanied by a signif icant increase in gastric microbleeding and gastric blood flow and tha t ASA promotes platelet/neutrophil adhesion that may resemble the neut rophil/endothelium interaction in the gastric mucosa.