SWELLING-STIMULATED PASSIVE POTASSIUM-TRANSPORT IN CAMEL ERYTHROCYTES- INHIBITORY EFFECTS OF FUROSEMIDE AND SODIUM-FLUORIDE

The inhibitory effects of furosemide, sodium fluoride, and age on volu me-dependent, ouabain-resistant K+ influx were investigated in camel r ed blood cells. Swelling of young camel erythrocytes hypotonically sti mulates ouabain-resistant potassium influx, a response that was lackin g in old camel erythrocytes. The swelling-stimulated influx was partia lly inhibited by 1 mm furosemide and by 10 and 20 mm sodium fluoride. The inhibitory effect of furosemide was significantly increased if rub idium was added to the flux media. There was a significant correlation between potassium influx in normo- and hypotonic media which might in dicate that the anion-dependent transport system operates, to some ext ent, to regulate cell volume.