CATIONIC POLYENE CYCLIZATIONS - A COMPUTER-ASSISTED SYNTHESIS APPROACH

Authors
BOITEN JW NOORDIK JH GROEN MB
Citation
Jw. Boiten et al., CATIONIC POLYENE CYCLIZATIONS - A COMPUTER-ASSISTED SYNTHESIS APPROACH, Journal of chemical information and computer sciences, 33(5), 1993, pp. 727-735
Citations number
53
Categorie Soggetti
Information Science & Library Science","Computer Application, Chemistry & Engineering","Computer Applications & Cybernetics",Chemistry
Journal title
Journal of chemical information and computer sciences → ACNP
ISSN journal
00952338
Volume
33
Issue
5
Year of publication
1993
Pages
727 - 735
Database
ISI
SICI code
0095-2338(1993)33:5<727:CPC-AC>2.0.ZU;2-C
Abstract
The implementation of cationic polyene cyclizations in a synthesis pla nning program requires a special approach which focuses primarily on t he synthetically useful cyclizations. This paper describes such an app roach which is based on the recognition of strategic disconnections in the skeleton of a target molecule. This approach has been implemented in the LHASA system. The output of this implementation is illustrated by a LHASA analysis of two synthetic target structures.