Atheroemboli-associated inflammatory type polyps localized to a portio
n of the sigmoid colon occurred in a 68-year-old diabetic man presenti
ng with a 2-year history of bloody diarrhea and abdominal pain. The pa
tient underwent segment resection of the sigmoid colon. The specimen c
ontained 15 polyps ranging from 0.3 to 1.9 cm in greatest dimension, l
ocalized to an 8-cm length of sigmoid colon. The polyps had an edemato
us submucosa with a superficially ulcerated mucosa. Microscopically, a
rterioles within the submucosa of the polyps contained organized ather
oemboli. The overlying mucosa was largely replaced by granulation tiss
ue, with foci of coagulation necrosis present in residual mucosa. The
remainder of the bowel was unremarkable. The histologic diagnosis of a
theroembolization to the gastrointestinal tract is difficult, requirin
g the inclusion of submucosa with atheroemboli in the biopsy tissue. I
schemic ulcers and erosions as well as inflammatory polyps related to
atheroemboli may require deeper biopsy for etiologic diagnosis.