THE INFLUENCE OF NEOSTIGMINE AND METOCLOPRAMIDE OR THEIR COMBINATION ON GASTRIC-EMPTYING

Authors
VANWYK M SOMMERS DK MONCRIEFF J BECKER PJ
Citation
M. Vanwyk et al., THE INFLUENCE OF NEOSTIGMINE AND METOCLOPRAMIDE OR THEIR COMBINATION ON GASTRIC-EMPTYING, Current therapeutic research, 54(3), 1993, pp. 300-303
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
Journal title
Current therapeutic research → ACNP
ISSN journal
0011393X
Volume
54
Issue
3
Year of publication
1993
Pages
300 - 303
Database
ISI
SICI code
0011-393X(1993)54:3<300:TIONAM>2.0.ZU;2-B
Abstract
The effect of a neostigmine-mediated increase in acetylcholine and its influence on metoclopramide's effect on gastric emptying was studied in six healthy volunteers by using the Wagner-Nelson method of calcula ting the fraction of paracetamol absorbed. Gastric emptying was not si gnificantly influenced by metoclopramide, but the combination of metoc lopramide and neostigmine had an effect similar to that of neostigmine alone. Metoclopramide did not significantly slow the ''hurrying'' eff ect of neostigmine.