IMMUNOSUPPRESSIVE PROPERTIES OF CALCIUM-CHANNEL BLOCKERS

Calcium channel blockers are extensively used for their beneficial eff ects on the cardiovascular system. Solid organ transplant recipients c ommonly have cardiovascular disease and are often treated with these a gents. Research demonstrates that calcium antagonists may have benefic ial effects in this population that are independent of their effects o n the cardiovascular system. Indeed, both in vitro and in vivo studies suggested that they may possess immunosuppressive properties. Their a ctions at the cellular level in both the afferent and efferent arms of the immune system indicate that alone, as well as in combination with cyclosporine, these agents possess immunosuppressive properties that may potentially benefit the transplant population.