One quarter to one third of Americans are over-weight; as many as 40%
of women and 24% of men are trying to lose weight at any given time; m
any have tried a variety of methods, such as diets, exercise, behavior
modification, and drugs. In controlled settings, participants who rem
ain in weight loss programs usually lose approximately 10% of their we
ight. However, one third to two thirds of the weight is regained withi
n 1 year, and almost all is regained within 5 years. For many overweig
ht persons, achieving and maintaining a healthy weight is a lifelong c
hallenge. Successful weight loss improves several cardiovascular risk
factors and diabetic control; effects on mortality are not clear. Seve
ral epidemiologic studies have found that weight loss is associated wi
th increased mortality but the reasons for weight loss were not known.
Survey data also confirm that many Americans who are not overweight,
particularly young women, are trying to lose weight, which may have ad
verse physical and psychological consequences. Because of the importan
ce of these issues, research on weight and on weight loss and control
should assume a high priority on the nation's health agenda.