MODULATION OF ALPHA-1-ACID GLYCOPROTEIN (AGP) GENE INDUCTION FOLLOWING HONEY-BEE VENOM ADMINISTRATION TO ADJUVANT ARTHRITIC (AA) RATS - POSSIBLE ROLE OF AGP ON AA DEVELOPMENT
M. Yiangou et al., MODULATION OF ALPHA-1-ACID GLYCOPROTEIN (AGP) GENE INDUCTION FOLLOWING HONEY-BEE VENOM ADMINISTRATION TO ADJUVANT ARTHRITIC (AA) RATS - POSSIBLE ROLE OF AGP ON AA DEVELOPMENT, Clinical and experimental immunology, 94(1), 1993, pp. 156-162
Honey bee venom (HBV) administration to adjuvant arthritic (AA) rats r
esulted in a significant suppression of arthritis and in suppression o
f the hepatic acute phase alpha1-acid glycoprotein (AGP) gene inductio
n at the early stages of disease development. AGP administration in AA
rats resulted in acceleration of arthritis development and in increas
e of severity and duration of the disease. IL-1, IL-6, tumour necrosis
factor (TNF) and glucocorticoids alone are not responsible for the HB
V-mediated AGP gene down-regulation. These results indicate that AGP g
ene expression in AA and HBV-treated AA rats involves the interaction
of several factors, and that AGP plays a role for AA development in ra
ts.