MODULATION OF ALPHA-1-ACID GLYCOPROTEIN (AGP) GENE INDUCTION FOLLOWING HONEY-BEE VENOM ADMINISTRATION TO ADJUVANT ARTHRITIC (AA) RATS - POSSIBLE ROLE OF AGP ON AA DEVELOPMENT

Authors
YIANGOU M KONIDARIS C VICTORATOS P HADJIPETROUKOUROUNAKIS L
Citation
M. Yiangou et al., MODULATION OF ALPHA-1-ACID GLYCOPROTEIN (AGP) GENE INDUCTION FOLLOWING HONEY-BEE VENOM ADMINISTRATION TO ADJUVANT ARTHRITIC (AA) RATS - POSSIBLE ROLE OF AGP ON AA DEVELOPMENT, Clinical and experimental immunology, 94(1), 1993, pp. 156-162
Citations number
34
Categorie Soggetti
Immunology
Journal title
Clinical and experimental immunology → ACNP
ISSN journal
00099104
Volume
94
Issue
1
Year of publication
1993
Pages
156 - 162
Database
ISI
SICI code
0009-9104(1993)94:1<156:MOAG(G>2.0.ZU;2-3
Abstract
Honey bee venom (HBV) administration to adjuvant arthritic (AA) rats r esulted in a significant suppression of arthritis and in suppression o f the hepatic acute phase alpha1-acid glycoprotein (AGP) gene inductio n at the early stages of disease development. AGP administration in AA rats resulted in acceleration of arthritis development and in increas e of severity and duration of the disease. IL-1, IL-6, tumour necrosis factor (TNF) and glucocorticoids alone are not responsible for the HB V-mediated AGP gene down-regulation. These results indicate that AGP g ene expression in AA and HBV-treated AA rats involves the interaction of several factors, and that AGP plays a role for AA development in ra ts.