CHROMOSOMAL LOCALIZATION OF THE OX-44 (CD53) LEUKOCYTE ANTIGEN GENE IN MAN AND RODENTS

Authors
TAGUCHI T BELLACOSA A ZHOU JY GILBERT DJ LAZO PA COPELAND NG JENKINS NA TSICHLIS PN TESTA JR
Citation
T. Taguchi et al., CHROMOSOMAL LOCALIZATION OF THE OX-44 (CD53) LEUKOCYTE ANTIGEN GENE IN MAN AND RODENTS, Cytogenetics and cell genetics, 64(3-4), 1993, pp. 217-221
Citations number
30
Categorie Soggetti
Cytology & Histology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
64
Issue
3-4
Year of publication
1993
Pages
217 - 221
Database
ISI
SICI code
0301-0171(1993)64:3-4<217:CLOTO(>2.0.ZU;2-Z
Abstract
The Ox-44 (CD53) leukocyte antigen contributes to the transduction of CD-generated signals in T cells and natural killer (NK) cells and has been suggested to play a role in growth regulation. The gene encoding this protein was assigned to the midportion of mouse chromosome 3 by i nterspecific backcross mapping and to human chromosome region 1p21-->p 13.3 and rat chromosome region 2q34-->q41 by fluorescence in situ hybr idization. Comparative mapping data presented in this report demonstra te conservation of synteny within the region encompassing this gene in mouse (Cd53), human (CD53), and rat (CD53).