H. Jaafar et al., CHROMOSOMAL-ANOMALIES AND DISTURBANCE OF TRANSCRIPTIONAL ACTIVITY AT THE PACHYTENE STAGE OF MEIOSIS - RELATIONSHIP TO MALE-STERILITY, Cytogenetics and cell genetics, 64(3-4), 1993, pp. 273-280
Morphological analysis of pachytene spermatocytes obtained from male m
ice carrying three chromosomal rearrangements - a Robertsonian translo
cation. Rb(X-2)2Ad; an autosomal reciprocal translocation, T(16;17)43H
; and a tertiary trisomic. Ts(113)70H - demonstrated frequent associat
ion between the XY bivalent and the T43H and T70H translocation chromo
somes. Quantitative autoradiographic data revealed that the normal tra
nscriptional inactivity of the XY bivalent was not significantly distu
rbed, in contrast to that of the 16;17 quadrivalent and the extra 1(13
) marker chromosome. These results are interpreted as an extension of
the XY inactivation process to the associated autosomes and discussed
in relation to male sterility.